Elaine
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Posts posted by Elaine
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Karen
It does suck. But one way to look at it is this: you would want all the people at very high risk to be able to have the shot. I think the shortage is for real. Wish there was some way around it.
Maybe there is a black market! (OK that's my stab at sick humor!)
elaine
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I also found that the Phase II is closed. Additionally, all sites are in Canada, but they may open some sites in US for Phase III.
elaine
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Clinical Trials - Offer patients new or experimental treatment programs and special agents for the treatment of cancer and blood diseases. Participation is 100% voluntary. Clinical trials involve these phases:
Phase 1 - Intended to determine the safe dose for anti-cancer medications and the potential side effects of different doses. I think Phase 1 trials also look to see if there are likely to be results in larger human populations.
Phase 2 - Intended to establish if a new treatment is effective for a particular kind of cancer.
Phase 3 - Intended to compare a "new" treatment with "standard" treatment. This type of trial involves "randomization," or the assignment of patients to one or the other treatment on a random basis. Each treatment has known benefits, but this kind of study will tell if one may be superior to the other.
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October 8, 2004
Genentech Inc. closed down 30 cents, or less than 1 percent, at $47.25 after spending much of the day up about 2 percent on an upgrade from Credit Suisse First Boston. CSFB said Avastin, the company's key colon cancer drug, is likely to post positive results from a late-stage study of its use for lung cancer. Mid-stage trials did not show any significant effect of Avastin in lung cancer patients, but CFSB said the phase III study is more targeted
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Epimmune Preparing Phase 2 Study of Cancer Vaccine Based on Positive Initial Human Results
Tuesday September 28, 7:30 am ET
SAN DIEGO, Sept. 28 /PRNewswire-FirstCall/ -- Epimmune Inc. (Nasdaq: EPMN - News) today announced plans for a Phase 2 study of its EP-2101 vaccine in patients with late stage non-small cell lung (NSCL) cancer, based on evidence of relevant biological responses in early clinical trials in both NSCL and colorectal cancer.
Analysis of the data from patients who completed the initial trials showed that EP-2101:
* was immunogenic with approximately 93% of the patients evaluated
responding to at least one epitope included in the vaccine;
* induced a multi-epitope response with approximately four vaccine
epitopes being the average number recognized by the patients evaluated
and approximately 53% of the patients evaluated responding to at least
five of the nine epitopes included in the vaccine; and
* was safe and well tolerated.
The goal of the Phase 2 study will be to correlate overall survival and clinical benefit to patients with the immunogenicity demonstrated in the Phase 1 trials.
The Phase 2 study will be conducted in stage IIIB/IV NSCL cancer patients with advanced disease as a single dose level, open-label study. The primary endpoints will be overall survival and safety. Secondary endpoints will be progression-free survival and vaccine immunogenicity. The study will be conducted by Epimmune in the United States and is expected to involve between 10 and 12 sites and enroll approximately 84 patients. Enrollment is expected to be complete by the end of 2005 and data from the study is expected to be available beginning in the second half of 2006.
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This is another vaccine--going into phase II trials.
http://biz.yahoo.com/prnews/040928/latu005_1.html
Epimmune Preparing Phase 2 Study of Cancer Vaccine Based on Positive Initial Human Results
Tuesday September 28, 7:30 am ET
SAN DIEGO, Sept. 28 /PRNewswire-FirstCall/ -- Epimmune Inc. (Nasdaq: EPMN - News) today announced plans for a Phase 2 study of its EP-2101 vaccine in patients with late stage non-small cell lung (NSCL) cancer, based on evidence of relevant biological responses in early clinical trials in both NSCL and colorectal cancer.
Analysis of the data from patients who completed the initial trials showed that EP-2101:
* was immunogenic with approximately 93% of the patients evaluated
responding to at least one epitope included in the vaccine;
* induced a multi-epitope response with approximately four vaccine
epitopes being the average number recognized by the patients evaluated
and approximately 53% of the patients evaluated responding to at least
five of the nine epitopes included in the vaccine; and
* was safe and well tolerated.
The goal of the Phase 2 study will be to correlate overall survival and clinical benefit to patients with the immunogenicity demonstrated in the Phase 1 trials.
The Phase 2 study will be conducted in stage IIIB/IV NSCL cancer patients with advanced disease as a single dose level, open-label study. The primary endpoints will be overall survival and safety. Secondary endpoints will be progression-free survival and vaccine immunogenicity. The study will be conducted by Epimmune in the United States and is expected to involve between 10 and 12 sites and enroll approximately 84 patients. Enrollment is expected to be complete by the end of 2005 and data from the study is expected to be available beginning in the second half of 2006.
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Quick question:
Are insurance companies turning down paying for Erbitux for lc???
Do you know?
elaine
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Kitkathi
Great double news!
elaine
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No need to apologize. Someone had to tell me that too! I had no idea. Like everything else, it depends on the context if someone will get offended by words they see in caps. I never thought you were shouting! I just thought you had your cap lock on!
love and fortitude
elaine
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Beverly.
I am sorry we had to meet this way. I dont have the knowledge to answer most of your questions. I did want you to know that Tarceva is being offered in an open access trial accross the country--I think now. Here is a link on this borad to further information.
http://lchelp.com/community/viewtopic.php?t=11485
I wish you strength as you make your upcoming decisions.
love and fortitude
elaine
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There once was a rich man who was near death. He was very sad because he had worked so hard for his money and he wanted to be able to take it with him to heaven. So he began to pray that he might be able to take some of his wealth with him.
An angel hears his plea and says to him... "Sorry, but you can't take your wealth with you." The man implores the angel to speak to God to see if He might bend the rules.
The man continues to pray that his wealth could follow him. The angel reappears and informs the man that God has decided to allow him to take one suitcase with him. Overjoyed, the man gathers his largest suitcase and fills it with pure gold bars and places it beside his bed.
Soon afterward the man dies and shows up at the Gates of Heaven to greet St. Peter. St. Peter seeing the suitcase says, "Hold on, you can't bring that in here!"
But, the man explains to St. Peter that he has permission and asks him to verify his story with the Lord. Sure enough, St. Peter checks and comes back saying, "You're right. You are allowed one carry-on bag, but I'm supposed to check its contents before letting it through."
St. Peter opens the suitcase to inspect the worldly items that the man found too precious to leave behind and exclaims - "You brought PAVEMENT????!!!!
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MJB
Sorry the news wasn't what you hoped. Ray A who is a member of the board recently had a met to one of his adrenals. He had the adrenal gland surgically removed. I don't know exactly what the criteria is for this but you might research it further.
love and fortitude
elaine
I just noticed that your husband has small cell. Ray has NSCLC and that might make a diference.
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Tina
My prayers are with your friend and her family. I am so sorry and pray they all find comfort.
elaine
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Kicking this one up! Thanks!
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Is Hell Endothermic or Exothermic? (Rated PG)
Dr. Schlambaugh, a senior lecturer at the Chemical
Engineering Department,University of Oklahoma, is known for posing
questions on final exams like: "Why do airplanes fly?"
In May a few years ago, the "Momentum, Heat and Mass
Transfer " exam paper contained the question:
"Is Hell exothermic or endothermic? Support your answer with
proof."
Most students wrote proofs of their beliefs using Boyle's
Law or similar. One student, however, wrote the following:
First, we must postulate that if souls exist, they must have
some mass. If they do, then a mole of souls also must have a mass. So,
at what rate are souls moving into hell and at what rate are souls
leaving? I think we can safely assume that once a soul gets to Hell, it does
not leave.
Therefore, no souls are leaving.
As for souls entering Hell, let's look at the different religions that
exist in the world today. Some religions say that if you are not a
member of their religion, you will go to Hell.
Since there are more than one of these religions, and people do not belong to more than one religion, we can project that all people and all souls go to Hell.
With the birth and death rates what they are, we can expect the
number of souls in Hell to increase exponentially.
Now, we look at the rate of change in the volume of Hell. Boyle's Law states that in order for the temperature and pressure in Hell to stay the same, the ratio of the mass of the souls and volume needs to stay constant.
[Answer 1] So, if Hell is expanding at a slower rate than the rate at
which souls enter Hell, then the temperature in Hell will increase until
all Hell breaks loose.
[Answer 2] Of course, if Hell is expanding at a rate faster
than the increase in souls in Hell, then the temperature and pressure
will drop until Hell freezes over.
So which is it? If we accept the postulate (given to me by
Teresa Banyan during freshman year) that "it'll be a cold day in Hell
before I sleep with you", and taking into account that I still have not
succeeded in having sexual relations with her, then [Answer 2] cannot be
correct;
...... thus, Hell is exothermic.
The student got the only A.
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John,
Uncannily, I thought the very same thing!
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Here's a list of actual English subtitled lines used in films made in Hong Kong
1. I am damn unsatisfied to be killed in this way.
2. Fatty, you with your thick face have hurt my instep.
3. Same old rules: no eyes, no groin.
4. A normal person wouldn't steal pituitaries.
5. Damn, I'll burn you into a BBQ chicken!
6. Who gave you the nerve to get killed here?
7. Quiet or I'll blow your throat up.
8. You always use violence. I should've ordered glutinous rice chicken.
9. Beat him out of recognizable shape!
10. I have been scared shitless too much lately.
11. I got knife scars more than the number of your leg's hair!
12. Beware! Your bones are going to be disconnected.
13. The bullets inside are very hot. Why do I feel so cold?
14. How can you use my intestines as a gift?
15. This will be of fine service for you, you bag of the scum. I am sure you will not mind that I remove your manhoods and leave them out on the dessert floor for your aunts to eat.
16. Yah-hah, evil spider woman! I have captured you by the short rabbits and can now deliver you violently to your gynecologist for a thorough extermination.
17. Greetings, large black person. Let us not forget to form a team up together and go into the country to inflict the pain of our karate feets on some *ss of the giant lizard person.
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If Kitty Carlisle married Conway Twitty, she'd be Kitty Twitty.
If Yoko Ono married Sonny Bono,she'd be Yoko Ono Bono.
If Bo Derek married Don Ho,she'd be Bo Ho.
If Cat Stevens married Snoop Doggy Dogg,(hey! it's the 21st century!),
he'd be Cat Doggy Dogg.
If Olivia Newton-John married Wayne Newton,then divorced him to
marry Elton John, she'd be Olivia Newton-John Newton John.
If Liv Ullman married Judge Lance Ito, then divorced him and
married Jerry Mathers, she'd be Liv Ito Beaver.
If Snoop Doggy Dogg married Winnie the Pooh, he'd be Snoop Doggy
Dogg Pooh.
If Ivana Trump married, in succession, Orson Bean (actor), King
Oscar (of Norway), Louis B. Mayer (of MGM), and Norbert Wiener
(mathematician), she would then be Ivana Bean Oscar Mayer Wiener.
If Woody Allen married Natalie Wood, divorced her and married
Gregory Peck, divorced him and married Ben Hur, he'd be Woody
Wood Peck Hur.
If Dolly Parton married Tommy Smothers, then went even further
back in show business and married Mr. Lucky, then divorced and
married Martin Short, then divorced and married football kicker
Ray Guy, we could all nod understandingly when we heard, "Dolly
Parton Smothers Lucky Short Guy."
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DAMITALL Take 2 and the rest of the world can go to hell for up to 8
hours.
ST. M O M M A'S W O R T Plant extract that treats mom's depression by
rendering preschoolers unconscious for up to six hours.
E M P T Y N E S T R O G E N Highly effective suppository that eliminates
melancholy by enhancing the memory of how awful they were as teenagers and how you couldn't wait till they moved out.
P E P T O B I M B O Liquid silicone for single women. Two full cups
swallowed before an evening out increases breast size, decreases
intelligence, colors hair blonde and improves flirting.
D U M B E R O L When taken with Peptobimbo, can cause dangerously low
IQ, resulting in enjoyment of country western music.
F L I P I T O R Increases life expectancy of commuters by controlling
road rage and urge to flip off other drivers.
M E N I C I L L I N Potent antiboyotic for older women. Increases
resistance to such lines as, "You make me want to be a better person
... can we get naked now?"
B U Y A G R A Injectable stimulant taken prior to shopping. Increases
potency and duration of spending spree.
J A C K A S S P I R I N Relieves headache caused by a man who can't
remember your birthday, anniversary or phone number.
A N T I-T A L K S I D E N T A spray carried in a purse or wallet to be
used on anyone too eager to share their life stories with total
strangers.
S E X C E D R I N More effective than Excedrin in treating the, "Not
now, dear, I have a headache" syndrome.
N A G A M E N T When administered to a husband, provides the same
irritation as nagging him all weekend, saving the wife the time and
trouble of doing it.
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SOME HMO FAQ'S
Q) I just joined a new HMO. How difficult will it be to choose the doctor I want?
A) Just slightly more difficult than choosing your parents. Your insurer will provide you with a book listing all the doctors who were participating in the plan at the time the information was gathered. These doctors basically fall into two categories--those who are no longer accepting new patients, and those who will see you but are no longer part of the plan. But don't worry--the remaining doctor who is still in the plan and accepting new patients has an office just a half a day's drive away.
Q) What does HMO stand for?
A) This is actually a variation of the phrase "Hey, Moe!" Its roots go back to a concept pioneered by Doctor Moe Howard, who discovered that a patient could be made to forget about the pain in his foot if he was poked hard enough in the eyes. Modern practice replaces the physical finger poke with hi-tech equivalents such as voice-mail and referral slips, but the result remains the same.
Q) Do all diagnostic procedures require pre-certification?
A) No. Only those you need.
Q) What are pre-existing conditions?
A) This is a phrase used by the grammatically challenged when they want to talk about existing conditions. Unfortunately we appear to be pre-stuck with it.
Q) Well, can I get coverage for my pre-existing conditions?
A) Certainly, as long as they don't require any treatment.
Q) What happens if I want to try alternative forms of medicine?
A) You'll need to find alternative forms of payment.
Q) My pharmacy plan only covers generic drugs, but I need the name brand. I tried the generic medication, but it gave me a stomach ache. What should I do?
A) Poke yourself in the eye.
Q) I have an 80/20 plan with a $200 deductible and a $2,000 yearly cap. My insurer reimbursed the doctor for my out-patient surgery, but I'd already paid my bill. What should I do?
A) You have two choices. Your doctor can sign the reimbursement check over to you, or you can ask him to invest the money for you in one of those great offers that only doctors and dentists hear about, like windmill farms or frog hatcheries.
Q) What should I do if I get sick while traveling?
A) Try sitting in a different part of the bus.
Q) No, I mean what if I'm away from home and I get sick?
A) You really shouldn't do that. You'll have a hard time seeing your primary care physician. It's best to wait until you return, and then get sick.
Q) I think I need to see a specialist, but my doctor insists he can handle my problem. Can a general practitioner really perform a heart transplant right in his office?
A) Hard to say, but considering that all you're risking is the $10 co-payment, there's no harm giving him a shot at it.
Q) What accounts for the largest portion of health care costs?
A) Doctors trying to recoup their investment losses.
Q)Will health care be any different in the next century?
A) No, but if you call right now, you might get an appointment by then.
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DEFINITIONS FOR ADULTS
BOSS: Someone who is early when you are late and late when you are early.
POLITICIAN: One who shakes your hand before elections and your confidence after.
OFFICE: A place where you can relax after your strenuous home life.
YAWN: Also, the only time some married men ever get to open their mouth.
ETC: A sign to make others believe that you know more than you actually do.
COMMITTEE: Individuals who can do nothing individually and sit to decide that nothing can be done together.
CLASSIC: A book which people praise, but do not read.
WORRY: Interest paid on trouble before it falls due.
EXPERIENCE: The name men give to their mistakes.
ATOM BOMB: An invention to end all inventions.
PHILOSOPHER: A fool who torments himself during life, to be spoken of when dead.
DIPLOMAT: A person who tells you to go to hell in such a way that you actually look forward to the trip.
OPTIMIST: A person who starts taking a bath if he accidentally falls into a river.
PESSIMIST: A person who says that O is the last letter in ZERO, instead of the first letter in word OPPORTUNITY .
CRIMINAL: A guy no different from the rest... except that he got caught.
SMILE: A curve that can set a lot of things straight.
RUMOR: News that travels at the speed of sound.
DICTIONARY: The only place where divorce comes before marriage.
ECSTASY: A feeling when you feel you are going to feel a feeling you have never felt before.
adult: A person who has stopped growing at both ends and is now growing in the middle.
COMMITTEE: A body that keeps minutes and wastes hours.
DUST: Mud with the juice squeezed out.
EGOTIST: Someone who is usually me-deep in conversation.
GOSSIP: A person who will never tell a lie if the truth will do more damage.
MOSQUITO: An insect that makes you like flies better.
SECRET: Something you tell to one person at a time.
TOMORROW: One of the greatest labor saving devices of today.
YAWN: An honest opinion openly expressed.
WRINKLES: Something other people have. You have character lines.
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THE DIVA'S PRAYER
Armani
Which Art in Hermes
Hallowed be thy Gucci
Thy Cartier watch
Thy Prada bag
on Rodeo
As it is in Tiffany's
Give us this day, our Visa Gold
And forgive us this overdraft
As we forgive those who stop our Mastercard
Lead us not into JC Penney
And deliver us from Sears
For thine is the Chanel, the Gaultier and the Versace
For Dolce and Gabbana
Amex
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Confuscious Say:
Man who walk through airport door sideways is going to Bangkok."
He who crosses the ocean twice without washing is a dirty double crosser."
"Man who tell one to many light bulb jokes soon burn out!"
"Woman who cooks carrots and peas in same pot is unsanitary."
"Man with no legs bums around."
"A bird in hand makes hard to blow nose."
"Find old man in dark, not hard!"
"Man who smoke pot choke on handle."
"Man who put head on Rail Road track to listen for train likely to end up with splitting headache."
"Passionate kiss like spider's web ... soon lead to undoing of fly."
"Baseball is wrong. Man with four balls cannot walk."
"Man who fight with wife all day, get no piece at night."
"Honeymooning campers have one intent!"
"Man who lays girl in field gets piece on earth."
"He who fish in other mans well often catches crabs."
"He who chase car will get exhausted."
"It takes many nails to build a crib, but one screw to fill it."
"He who stand on toilet, high on pot."
"Foolish man give wife grand piano. Wise man give wife upright organ."
"All men eat, but Fu Manchu."
"He who eat ice cream in car is a Sundae Driver."
"He who eat too many prunes, sit on toilet many moons."
"He who put face in punch bowl get punch in nose."
"He who stick head in open window get pane in neck."
"He who stick head in oven get baked bean."
"House without toilet, uncanny."
"If you turn an oriental around, he become disoriented."
"If you want pretty nurse, you got to be patient."
"Man who abuse his computer get bad bytes!"
"Man who drive like hell bound to get there!"
"Man who drop watch in whisky is wasting time."
"Man who eat photo of father, soon spitting image of father."
"Man fall in vat of molten glass make spectacle of self."
"Man who have circumcision lose a bit of foresight."
"Man who jump off cliff jump to conclusion!"
"Man who read woman like book, prefer braille!"
"Man who sit on hot stove will rise again."
"Man who sit on tack get point!"
"Man who sleep in cat house by day, in doghouse by night"
"Man with forked tongue not need chop sticks."
"Man with hand in bush not necessarily trimming shrubs."
Squirrel who runs up woman's leg not find nuts."
"Woman who put detergent on top shelf, Jump for Joy."
Another Flu Shot Question - for Caregivers
in CAREGIVER RESOURCE CENTER
Posted
I called today, too, and my husband can't have one......(he was kind of happy about it
). So what does a person do if no one will give him or her a shot????
elaine