Can't help on the brain mets, but the spine we can input on. Lucie, my wife, had the main met on her upper spine, which was very painful and caused some functional loss in her left hand. It was treated with radiation, as well as chemo, two years ago, and it has been fine for far. She does have to take low doses of time-release morphine twice a day because the damage to the spine still causes pain. She drives some, and does most of the things she did before. Good luck. Don