Margaret,
My father completed chemo and radiation several months ago, started taking Iressa a couple of weeks ago, and for the last month or so has had increasing swelling in his feet, ankles and now halfway up his legs. His primary tumor was in his left lung, and he has mets now in right lung. The swelling is worse in his left leg, but significant in his right leg as well. Also, he is continually losing his voice -- it has become very weak and raspy, he is becoming more and more confused, and is experiencing increasing fatigue and shortness of breath. Not sure what all this means, but he had new scans today and will see his medical oncologist this Wednesday. Hopefully we will get some questions answered then. I've been wondering about dehydration and/or anemia being part of the cause of the swelling -- hope to get some questions answered this week. Sorry I can't be of more help to you.