Shirley,
My reaction to your same drugs were very similar. I don't believe that the effects are cumulative because when I was going for my last treatment, I was really nervous about that, and it was my very best one (no reaction at all).
Just be very sure, even if you're not hungry, to DRINK lots of water, juice or whatever you can get down. I liked the ensure and it also filled me up, but whatever you like, liquids are imperative!
Its very easy to become dehydrated while undergoing chemo.
Just don't worry, you'll be fine. Stay positive.
Joan