Don M Posted January 8, 2008 Share Posted January 8, 2008 I guess the cyberknife did not work. I start tarceva tomorrow. I have been taking curcumin with bioperine and bioperine. I asked my local oncologist about the bioperine. He did not know anything about it. I have heard that one should not take bioperine with tarceva because it makes the tarceva too available to the bloodstream. Does anyone here know anything about that? Don M Quote Link to comment Share on other sites More sharing options...
Welthy Posted January 9, 2008 Share Posted January 9, 2008 Oh Don, our mighty warrior! I'm sorry to hear about the progression, but glad you have some options. Here's to Tarceva and some good things happening for you! Welthy Quote Link to comment Share on other sites More sharing options...
shineladysue Posted January 9, 2008 Share Posted January 9, 2008 Don, it is so hard to read all the troubles you are having . You have always been such an inspiration and such a contributor to all of us. I know what a fighter you are and I know you will continue to give this fight your all. We all know that Tarceva has been known to do some miraculous things for some people. I am praying you will be one of those people. God Bless, Sue Quote Link to comment Share on other sites More sharing options...
Shelley (MLC) Posted January 9, 2008 Share Posted January 9, 2008 Sorry Don!!! I wish you the very best results with the Tarceva. It's time to turn this around! Shelley Quote Link to comment Share on other sites More sharing options...
Leela Posted January 9, 2008 Share Posted January 9, 2008 Wishing and hoping for improvement for you Don. Hugs, Lisa Quote Link to comment Share on other sites More sharing options...
tiredmom959 Posted January 9, 2008 Share Posted January 9, 2008 I hope you have the best results possible on the Tarceva ... you deserve it. Quote Link to comment Share on other sites More sharing options...
carolhg Posted January 9, 2008 Share Posted January 9, 2008 I certainly hope that you get good results from the tarceva Don. Carol Quote Link to comment Share on other sites More sharing options...
Maryanne Posted January 9, 2008 Share Posted January 9, 2008 Ah Don, So sorry the cyberknife did not work, But that was something you thought would happen as they could not give your the correct dosage. I am so sorry I know how bad you wanted that to work. We all did. I hope you get some answers to your question. I pray the tarceva works for you. I just cant believe all you have been through since you wee first diagnoised with an early stage. I hate the f'en disease. Keep hanging strong as you are one of the strongest people on this board. You are a trooper and just keep trying one treatment after another. I have a feeling this one will work. Maryanne Quote Link to comment Share on other sites More sharing options...
beatlemike Posted January 9, 2008 Share Posted January 9, 2008 Don,Im hoping and praying that the tarceva works well for you. Quote Link to comment Share on other sites More sharing options...
J.C. Posted January 9, 2008 Share Posted January 9, 2008 Don, All I know is that antioxydant sometimes are not good taken at with chemo....could you ask at www.BIOPERINE.com and get an answer. Hoping the Traceva works well for you. Jackie Quote Link to comment Share on other sites More sharing options...
Nova Posted January 9, 2008 Share Posted January 9, 2008 Don, You've been "my main man", since I first came to this board, so I'm hoping and praying that the Tarceva works miracles for you. I don't know anything at all about the drugs you mentioned, but I hope it all comes together perfectly, to get you back on the right, healthy track to remission. Nova Quote Link to comment Share on other sites More sharing options...
Patkid Posted January 9, 2008 Share Posted January 9, 2008 I have no helpful information, Don, but you know how much I admire you and how much Brian looked up to you. As always, you are have a special place in my heart and in my prayers. Go Tarceva, Go!!! Love P Quote Link to comment Share on other sites More sharing options...
cat127 Posted January 9, 2008 Share Posted January 9, 2008 I'm working on Don's question. I have an email in to a friend who is a clinical pharmacologist. When you hear things like - don't take drug A with drug B, it is the clinical pharmacologists who are saying that. His first response was that he didn't know anything about it and he'd have to look into it for me, and naturally the only thing I could quickly find online ws someone selling it and those sites tend to not be very informative scientifically. But I hope to have an answer for you sometime today Don! Quote Link to comment Share on other sites More sharing options...
Dollfinn Posted January 9, 2008 Share Posted January 9, 2008 Don~ You go get 'em again. enrol? I'll cruz around the boards for him. He seems to have alot of info on "alternative" meds. Doing the go Tarceva dance for you. Mary Quote Link to comment Share on other sites More sharing options...
wendyr Posted January 9, 2008 Share Posted January 9, 2008 Don, so sorry to hear this latest news but hoping Tarceva will work it's miracle for you. Maurice has been on it for a year and although he has had no shrinkage, he has remained stable. I wish 'stable' for you wendyr Quote Link to comment Share on other sites More sharing options...
cat127 Posted January 9, 2008 Share Posted January 9, 2008 Bioperine will inhibit the liver enzyme CYP3A4. Tarecva is metabolized primarily by CYP3A4. When Tarceva was approved tests done with various compounds that interact with liver enzymes showed that a drug called ketoconazole, which is sort of our worst case scenario at inhibiting CYP3A4, caused the AUC (a measure of the blood levels over time) to increase by 2/3 compared to without ketoconazole. So you were told correctly, it will increase blood levels of Tarceva and would be contraindicated. Quote Link to comment Share on other sites More sharing options...
blaze100 Posted January 10, 2008 Share Posted January 10, 2008 Hi Don, Looks like CAT got the answer above. I am so sorry you have to move to Tarceva. I know you've been having some gurgling sounds. Some of my students and my husband have had a really awful respiratory illness/pneumonia that lasted about 3 weeks...I was hoping this was all you had, but sounds like your doc decided otherwise? How did they decide this was progression? Was your breathing just getting worse instead of better? Barb Quote Link to comment Share on other sites More sharing options...
neilb Posted January 10, 2008 Share Posted January 10, 2008 Don--Sorry to hear that. Good luck with Tarceva. I had heard the same explanation that Cat reported. Go get'em!--Neil Quote Link to comment Share on other sites More sharing options...
Muriel Posted January 10, 2008 Share Posted January 10, 2008 Don, I'm sorry the cyberknife didn't work. Prayers that tarceva works for you. Muriel Quote Link to comment Share on other sites More sharing options...
lc46 Posted January 10, 2008 Share Posted January 10, 2008 Don-I don't know anything about Tarceva but I hope it works for you!! Dar Quote Link to comment Share on other sites More sharing options...
Kasey Posted January 10, 2008 Share Posted January 10, 2008 Good luck, Don. You know I'm cheering you on every step of the way. Kasey Quote Link to comment Share on other sites More sharing options...
Don M Posted January 10, 2008 Author Share Posted January 10, 2008 Thanks a lot Cat for your efforts. I think others will benefit also from your information. I think I will pass it on to my local oncologist. Barb, I recently went from 40 mg to 50 mg of prednisone when my breathing and coughing and congestion got worse. It did not help much. So, the assumption is that the tumor may be growing and is blocking free drainage of fluids through my lung. So, I am going on tarceva in hopes of getting some shrinkage. My next scan is in 2 months. That should be plenty of time to see if the tarceva will work or not. I don’t need oxygen and I can still walk a mile on flat ground. One good thing is that it is all still encased in my upper right lobe. Thanks everybody for your good wishes. Don M Quote Link to comment Share on other sites More sharing options...
trish2418 Posted January 10, 2008 Share Posted January 10, 2008 Wishing you lots of good luck with Tarceva, Don. It worked wonders for me for 18 months. Hope it works 10 times that long for you. Trish Quote Link to comment Share on other sites More sharing options...
Tiny Posted January 10, 2008 Share Posted January 10, 2008 Don- I always look for your posts on my intermittent visits, so am distressed about the latest news. Praying the Tarceva kicks in and gives you relief and positive results. Quote Link to comment Share on other sites More sharing options...
kamataca Posted January 10, 2008 Share Posted January 10, 2008 Praying that Tarceva will be the magic for you that it is for so many others. You are a giant for me. I pray this tx will help. Kelly Quote Link to comment Share on other sites More sharing options...
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